| ###Protect Your Health From The Effects Of AGEs - By Dr. Michael Cutler on 02/18/2011
It’s true that your body needs sugar. But excess sugar is causing a real problem in the form of Advanced Glycation End-products, or AGEs for short.
AGEs are the mutant molecules formed when rogue sugar molecules attach themselves to healthy proteins, lipids or various types of cells and tissues in your body.
These AGEs can secretly accumulate in your body under your immune system’s radar, rob your healthy cells of essential nutrients and cause any number of health problems…
•Hardened eye lenses leading to cloudy vision
•Stiff, inflexible arteries making blood flow difficult
•Damaged collagen in skin cells creating premature aging and wrinkles
•Inflammation in your brain cells hindering your memory recall
•Impaired nephrons—filter units—in the kidneys hindering healthy kidney function
Unfortunately, until a decade ago scientists knew the AGEs problem existed, but they considered it a normal part of the aging process. However, researchers such as Anthony Cerami, Ph.D., of Rockefeller University in New York have now proven that certain nutrients can help deter the formation of AGEs as well as help remove existing AGEs from the cells of your body.
These anti-glycation nutrients include…
•Carnosine(=beta-alanyl L-histidine)—this di-peptide can help block sugar molecules from cross-linking with collagen (natural protein that keeps your skin smooth and soft) which helps protect skin elasticity and slows premature aging.
•Histidine—in combination with carnosine it helps inhibit protein glycation, which is beneficial not only for your collagen skin cells, but all protein cells in your body including your brain, veins and kidneys.
•N-Acetyl Cysteine (NAC)—a powerful antioxidant that also helps prevent sugar molecules from cross-linking with protein cells such as those in your eye lenses and kidneys.
•L-Arginine—an amino acid that helps protect protein cells and helps boost collagen to repair wounds in burn patients.
Although the body does need some sugar to create energy and keep you alive, excessive sugar is detrimental to your health. But by using these natural nutrients you can help protect your body from the negative effects of the sugar that it cannot handle, and which can result in health-threatening AGE
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***AGE's 생성 경로
----methylGlyoxal(MGO.....글루타치온에 의해 중화됨) + 대개 동물성식단에서 유래함[아미노그룹(arginine, lysine) , 티올그룹(cysteine residues) ] --->AGE생성(신경말단부에 부착하여 염증 야기,,,, DMneuropathy 유발......당화혈색소 증가 유발...또한, .LDL과ㅣ 결합하여 동맥경화반 형성 4배이상 증가....이제 그 MGO독성이 광범하다는 것이 입증됨)
==>AGE형성 차단 ::: 비타민(Vitamin C, benfotiamine, pyridoxamine), 아미노산(alpha-lipoic acid taurine pimagedine<=aminoguanidine>) 에너지부스터(carnosine) 당뇨병약(metformin, pioglitazone,) 혈류개선제(aspirin, pentoxifylline)
==>AGE 독성을 예방 : ::: natural phenols(resveratrol and curcumin) |
제 목 : AGE-진행성당화최종산물
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